The development of innovative drugs is becoming more difficult while relying on empirical approaches. This inspired all major pharmaceutical companies to pursue alternative model-based paradigms. The key question is: How to find innovative compounds and, subsequently, appropriate dosage regimens? Written from the industry perspective and based on many years of experience, this book offers: - Concepts for creation of drug-disease models, introduced and supplemented with extensive MATLAB programs - Guidance for exploration and modification of these programs to enhance the understanding of key principles - Usage of differential equations to pharmacokinetic, pharmacodynamic and (patho-) physiologic problems thereby acknowledging their dynamic nature - A range of topics from single exponential decay to adaptive dosing, from single subject exploration to clinical trial simulation, and from empirical to mechanistic disease modeling. Students with an undergraduate mathematical background or equivalent education, interest in life sciences and skills in a high-level programming language such as MATLAB, are encouraged to engage in model-based pharmaceutical research and development.
Particulate discrete element analysis is becoming increasingly popular for research in geomechanics as well as geology, chemical engineering, powder technology, petroleum engineering and in studying the physics of granular materials. With increased computing power, practising engineers are also becoming more interested in using this technology for analysis in industrial applications. This is the first single work on Discrete Element Modelling (DEM) providing the information to get started with this powerful numerical modelling approach.
Written by an independent author with experience both in developing DEM codes and using commercial codes, this book provides the basic details of the numerical method and the approaches used to interpret the results of DEM simulations. Providing a basic overview of the numerical method, Particulate Discrete Element Modelling discusses issues related to time integration and numerical stability, particle types, contact modelling and boundary conditions. It summarizes approaches to interpret DEM data so that users can maximize their insight into the material response using DEM. The aim of this book is to provide both users and prospective users of DEM with a concise reference book that includes tips to optimize their usage.
Particulate Discrete Element Modelling is suitable both for first time DEM analysts as well as more experienced users. It will be of use to professionals, researchers and higher level students, as it presents a theoretical overview of DEM as well as practical guidance on running DEM simulations and interpreting DEM simulation data.
Multiscale modeling is becoming essential for accurate, rapid simulation in science and engineering. This book presents the results of three decades of research on multiscale modeling in process engineering from principles to application, and its generalization for different fields. This book considers the universality of meso-scale phenomena for the first time, and provides insight into the emerging discipline that unifies them, meso-science, as well as new perspectives for virtual process engineering.
Multiscale modeling is applied in areas including:
Jinghai Li is Vice-President of the Chinese Academy of Sciences (CAS), a professor at the Institute of Process Engineering, CAS, and leader of the EMMS (Energy-minimizing multiscale) Group.
Wei Ge, Wei Wang, Ning Yang and Junwu Wang are professors at the EMMS Group, part of the Institute of Process Engineering, CAS.
Xinhua Liu, Limin Wang, Xianfeng He and Xiaowei Wang are associate professors at the EMMS Group, part of the Institute of Process Engineering, CAS.
Mooson Kwauk is an emeritus director of the Institute of Process Engineering, CAS, and is an advisor to the EMMS Group.
Teaching physical education is a challenging but rewarding occupation. Finding a way into the profession can be a daunting task while regular changes in government policy can make it hard to stay up to date. This engaging new book explains the process of becoming and being a teacher of secondary school physical education, from the various routes of entry into the profession, to the realities of being a qualified PE teacher, to the ways in which experienced teachers can become teacher educators and nurture the next generation. It combines rich personal accounts of teaching in, and being taught, physical education, with practical advice for trainees, newly qualified teachers and established professionals, with an emphasis throughout on the importance of critical self-reflection.
The book begins by exploring the nature and purpose of physical education and examining the historical development of initial teacher training. It examines recent changes in training, policy and curriculum, and offers an overview of the various ways of becoming a PE teacher, including the Post Graduate Certificate in Education (PGCE) and school and employment based routes. The book offers advice on what to expect at interview, meeting the standards for qualifying to teach, and on how to survive the difficult first year as a newly-qualified teacher. It also outlines the challenges and rewards of being a qualified teacher, mentor or curriculum leader, as well as a teacher educator within higher education.
Concise, helpful, and filled with sensible insights based on real experiences of teaching physical education, Becoming a Physical Education Teacher is an essential read for anybody considering entering the profession, or for students, trainees, newly qualified or experienced teachers wanting to understand better the process of becoming, and being, a successful PE teacher.
Group work is a popular and widely used social work method. Focusing particularly on the central role of mutual aid in effective group work, this text presents the theoretical base, outlines core principles, and introduces the skills for translating those theories and principles into practice.
A Mutual-Aid Model for Social Work with Groups will help readers to catalyze the strengths of group members such that they become better problem solvers in all areas of life from the playroom to the boardroom. Increased coverage of evaluation and evidence-based practice speaks to the field's growing concern with monitoring process and assessing progress. The book also includes:
Case examples are used throughout to help bridge the gap between theory and practice, and exercises for class or field, help learners to immediately apply conceptual material to their practice. All resources required to carry out the exercises are contained in over 20 appendices at the end of the book. Key points at the end of each chapter recap the major concepts presented, and a roster of recommended reading for each chapter points the reader to further resources on each topic.
Designed to support ethical and successful practice, this textbook is an essential addition to the library of any social work student or human service practitioner working with groups.
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