The development of innovative drugs is becoming more difficult while relying on empirical approaches. This inspired all major pharmaceutical companies to pursue alternative model-based paradigms. The key question is: How to find innovative compounds and, subsequently, appropriate dosage regimens? Written from the industry perspective and based on many years of experience, this book offers: - Concepts for creation of drug-disease models, introduced and supplemented with extensive MATLAB programs - Guidance for exploration and modification of these programs to enhance the understanding of key principles - Usage of differential equations to pharmacokinetic, pharmacodynamic and (patho-) physiologic problems thereby acknowledging their dynamic nature - A range of topics from single exponential decay to adaptive dosing, from single subject exploration to clinical trial simulation, and from empirical to mechanistic disease modeling. Students with an undergraduate mathematical background or equivalent education, interest in life sciences and skills in a high-level programming language such as MATLAB, are encouraged to engage in model-based pharmaceutical research and development.
Particulate discrete element analysis is becoming increasingly popular for research in geomechanics as well as geology, chemical engineering, powder technology, petroleum engineering and in studying the physics of granular materials. With increased computing power, practising engineers are also becoming more interested in using this technology for analysis in industrial applications. This is the first single work on Discrete Element Modelling (DEM) providing the information to get started with this powerful numerical modelling approach.
Written by an independent author with experience both in developing DEM codes and using commercial codes, this book provides the basic details of the numerical method and the approaches used to interpret the results of DEM simulations. Providing a basic overview of the numerical method, Particulate Discrete Element Modelling discusses issues related to time integration and numerical stability, particle types, contact modelling and boundary conditions. It summarizes approaches to interpret DEM data so that users can maximize their insight into the material response using DEM. The aim of this book is to provide both users and prospective users of DEM with a concise reference book that includes tips to optimize their usage.
Particulate Discrete Element Modelling is suitable both for first time DEM analysts as well as more experienced users. It will be of use to professionals, researchers and higher level students, as it presents a theoretical overview of DEM as well as practical guidance on running DEM simulations and interpreting DEM simulation data.
Multiscale modeling is becoming essential for accurate, rapid simulation in science and engineering. This book presents the results of three decades of research on multiscale modeling in process engineering from principles to application, and its generalization for different fields. This book considers the universality of meso-scale phenomena for the first time, and provides insight into the emerging discipline that unifies them, meso-science, as well as new perspectives for virtual process engineering.
Multiscale modeling is applied in areas including:
Jinghai Li is Vice-President of the Chinese Academy of Sciences (CAS), a professor at the Institute of Process Engineering, CAS, and leader of the EMMS (Energy-minimizing multiscale) Group.
Wei Ge, Wei Wang, Ning Yang and Junwu Wang are professors at the EMMS Group, part of the Institute of Process Engineering, CAS.
Xinhua Liu, Limin Wang, Xianfeng He and Xiaowei Wang are associate professors at the EMMS Group, part of the Institute of Process Engineering, CAS.
Mooson Kwauk is an emeritus director of the Institute of Process Engineering, CAS, and is an advisor to the EMMS Group.
"Richard Slimbach has skillfully taken on a gargantuan task in writing a comprehensive guide to global learning. His broad reach to students, volunteers and other global travelers is held together by a search for the common good defined as 'the healing of a broken world.' The resulting pedagogy for global learning guides the reader through a process of focused reflection, information and preparation to consider both ultimate purposes and practical learning strategies for entering deeply into another host culture. This is a much needed and valuable resource for both faculty and students engaged in global learning."? Orval Gingerich, Assistant Vice President of International Programs at Augsburg College
The Black Sea ecosystem is a unique marine environment. Its isolation from the ocean and large catchment basin, covering industrial and rural parts of the European and Asian continents, render the Black Sea ecosystem extremely vulnerable to the imposed environmental burdens Complex scientific problems related to the recent evolution of the Black Sea ecosystem were tackled in the framework of the NATO TU BLACK SEA project 'Ecosystem modelling as a management tool for the Black Sea', implemented between 1993 and 1997. The primary results and the products of the TU BLACK SEA project were presented to the scientific community at a dedicated symposium held on 15-19 June, 1997 at Zori Rossii on the Crimean coast of the Black Sea. The present two volumes contain 47 of the papers presented at the symposium, selected by peer review. Volume I contains 27 papers in all, two on the NATO TU Black SEA database and database management system, eight on the Black Sea biogeochemistry, and 17 on the biological structure of the basin. Of the 20 papers appearing in Volume II, nine are physical processes and 11 are on the modelling of the circulation and the ecosystems of the Black Sea.
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