The development of innovative drugs is becoming more difficult while relying on empirical approaches. This inspired all major pharmaceutical companies to pursue alternative model-based paradigms. The key question is: How to find innovative compounds and, subsequently, appropriate dosage regimens? Written from the industry perspective and based on many years of experience, this book offers: - Concepts for creation of drug-disease models, introduced and supplemented with extensive MATLAB programs - Guidance for exploration and modification of these programs to enhance the understanding of key principles - Usage of differential equations to pharmacokinetic, pharmacodynamic and (patho-) physiologic problems thereby acknowledging their dynamic nature - A range of topics from single exponential decay to adaptive dosing, from single subject exploration to clinical trial simulation, and from empirical to mechanistic disease modeling. Students with an undergraduate mathematical background or equivalent education, interest in life sciences and skills in a high-level programming language such as MATLAB, are encouraged to engage in model-based pharmaceutical research and development.
Multiscale modeling is becoming essential for accurate, rapid simulation in science and engineering. This book presents the results of three decades of research on multiscale modeling in process engineering from principles to application, and its generalization for different fields. This book considers the universality of meso-scale phenomena for the first time, and provides insight into the emerging discipline that unifies them, meso-science, as well as new perspectives for virtual process engineering.
Multiscale modeling is applied in areas including:
Jinghai Li is Vice-President of the Chinese Academy of Sciences (CAS), a professor at the Institute of Process Engineering, CAS, and leader of the EMMS (Energy-minimizing multiscale) Group.
Wei Ge, Wei Wang, Ning Yang and Junwu Wang are professors at the EMMS Group, part of the Institute of Process Engineering, CAS.
Xinhua Liu, Limin Wang, Xianfeng He and Xiaowei Wang are associate professors at the EMMS Group, part of the Institute of Process Engineering, CAS.
Mooson Kwauk is an emeritus director of the Institute of Process Engineering, CAS, and is an advisor to the EMMS Group.
An autobiography of a ground-breaking medical doctor. Dr. David A. Hamburg started as a medical student with interest in stress disorders, paying special attention to the propensity toward violence, including the evolution of human aggression. This lead him on a path to becoming one of the most highly celebrated doctors in America - he was a member of President Clinton's Committee of Advisors on Science and Technology and was awarded the Presidential Medal of Freedom (the highest civilian award of the United States). Most recently, he chaired committees at the United Nations and European Union on the prevention of genocide. This book will be inspirational for emerging scientists today.
What is the reality of being a midwife in the twenty-first century? What is it like to help and support women throughout pregnancy and childbirth and into motherhood? What roles can midwives play in society?
This new edition of the popular text, Becoming a Midwife, explores what it is to be a midwife, looking at the factors that make midwifery such a special profession, as well as some of the challenges. The fully updated chapters cover a variety of settings and several different stages in a woman's pregnancy, including stories from midwives working in hospitals and in the community, as managers, supervisors and educators, and as men, women, mothers and birth activists. All chapters are narrated by contributors who introduce their own theme, recount a vignette that throws light on their understandings of midwifery and reasons for becoming (or not becoming) a midwife and any subsequent career moves. Backed up by commentaries and drawing together these insights, the editors show what it means to be a midwife today.
Suitable for those contemplating a career in midwifery and providing an opportunity for reflection for more experienced midwives, this thought-provoking book is an invaluable contribution to midwifery.
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